"O you who have believed, upon you is [the responsibility for] your own souls," meaning: if it is not accepted from you.
﴿يَا أَيهَا الَّذين آمنُوا عَلَيْكُم أَنفسكُم﴾ يَعْنِي: إِذَا لَمْ يُقْبَلْ مِنْكُمْ.