"And [who] oppose the Messenger," meaning: they parted from him and showed him hostility, "after the guidance has become clear to them," meaning: after the proof was established against them, "they will never harm Allah at all" by their disbelief, "and He will render their deeds worthless."
﴿وشاقوا الرَّسُول﴾ فارقوه وعادوه ﴿مِنْ بَعْدِ مَا تبين لَهُم الْهدى﴾ من بعد مَا قَامَت عَلَيْهِم الحُجَّة ﴿لَنْ يَضُرُّوا اللَّهَ شَيْئًا﴾ بكفرهم ﴿وسيحبط أَعْمَالهم﴾.